María Blasco Secondary School was created in the 2008/2009 school year under the name of Secondary School Number 5 as a result of the split of the former Secondary School Canastell (Decree 188/2008 of the Consell, DOCV of 2 December 2008). The centre is designed to cater for up to 720 students in Compulsory Secondary Education (24 units) and 280 in Baccalaureate (8 units). IES Canastell is constituted this same academic year as an integrated vocational training centre and the then called IES Number 5 takes over its ESO and Baccalaureate teachings and the teaching staff assigned to them. As a consequence of the creation of the new institute, the assignment of schools to secondary schools is reorganised and the CEIP Azorín, Jaume I, José Ramón García Antón and Juan Ramón Jiménez are assigned to IES Número 5 (Order of 11 December 2008 of the Regional Ministry of Education, DOCV of 3 February 2009). The centre is assigned to teach Compulsory Secondary Education and the baccalaureate courses of Science and Technology, Humanities and Social Sciences, the latter in the daytime and evening modalities.
In its second year of operation (2009/2010) it would also incorporate teachings of Basic Qualification Training Programmes and, when these disappeared, of Basic Vocational Training studies, firstly, of the speciality of Administrative Services (2014/2015), and later also of Electricity and Electronics (2015/2016). In October 2013, following the proposal of the School Council of the centre and the Municipal School Council, the current name was changed to María Blasco Secondary School (Resolution of 18 October 2013, of the Regional Ministry of Education, Culture and Sport, DOCV of 25 October 2013). The need for space due to the continuous increase in enrolment led to a request for the construction of two new classrooms which were added to the centre in the 2020/2021 academic year.